Center for Cell Reprogramming

Researchers from Georgetown University Medical Center including CCR's own Ewa Krawczyk, have identified a biological pathway that is activated when tissue is starved of oxygen due to rapid growth of a tumor, thereby allowing cancer cells to make genetic changes so they can metastasize to the bone and thrive even when exposed to chemotherapy.

Biological pathways found that drive genomic changes and bone metastasis in ewing sarcoma, a rare childhood cancer In studies using mice grafted with human Ewing sarcoma tissue, researchers have identified a biological pathway that is activated when tissue is starved of oxygen due to rapid growth of a tumor, thereby allowing cancer cells to make genetic changes so they can metastasize to the bone and thrive even...

A recent publication featuring CCR's Dr. Ewa Krawczyk is now out on Frontiers in Cell and Developmental Biology article. Read about how “Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation”.

Neuropeptide Y/Y5 Receptor Pathway Stimulates Neuroblastoma Cell Motility Through RhoA Activation Neuropeptide Y (NPY) has been implicated in the regulation of cellular motility under various physiological and pathological conditions, including cancer dissemination. Yet, the exact signaling pathways leading to these effects remain unknown. In a pediatric malignancy, neuroblastoma (NB), high NPY....