Shearer Lab

Hey everybody, asking for your participation in a COVID19 survey sponsored by colleagues in the CoM.
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Penn State COVID-19 Online Survey regarding COVID-19 Pandemic - PennState College of Medicine - Powered by SurveyHero.com

We are so proud of Dr. Shue Huang, who received her PhD in Nutrition Saturday, Dec 14th. Dr. Huang brought epidemiological talent to our lab. Her dissertation work demonstrated moderate alcohol intake is associated with improved HDL levels (HDL is the “good” cholesterol), however, that improvement is not related to the decreased risk for heart attacks. In other words, moderate alcohol intake reduces risk for heart attacks, but not because it increases HDL. This finding is important to understanding both the benefits of alcohol as well as how therapies aimed at HDL metabolism might (or might not) work. A few notables about her work: she won or placed in soo many ASN competitions, its hard to list them. Shue has already co-authored seven peer reviewed papers, two as first author, and she has multiple first-author works under review. She worked with populations in the USA (the Multi-Ethnic Study of Atherosclerosis, aka MESA) and the Kailuan cohort from China (over 100k participants!). She used the causal mediation inference method, and taught me so much about mediation analysis and epidemiology in general. Shue was co-mentored by Dr. Xiang Gao (Thanks Xiang, a formal epidemiologist) and she goes on to postdoctoral work with Andrew Odegaard at UC Irvine SoM. The formal title of her dissertation is “The Role of High Density Lipoprotein for Alcohol Intake and Myocardial Infarction: Results from Two Prospective Cohorts”. Congratulations Shue!

Kudos to our own Shue Huang and all our Penn State colleagues!

Some good ideas in here. Be ready!

Nine Tips for Researchers to Enjoy Their Holidays, Even Mid-Study - Life in the Lab Whether you are going out of town or staying home for the holidays, researchers plan for the special challenges that happen during this time of year. With delicate equipment, cultured cells, and possibly animals, leaving the laboratory can put these valuable resources at risk. Here are some prepar....

This article shows two important findings:
1) In comparison to healthy people, those with pre-diabetes have lipid signaling patterns that are altered towards a more pro-inflammatory phenotype.
2) Treatment of the pre-diabetic subjects with prescription omega-3 fatty acids corrects part, but not all, of the inflammatory signaling

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