Seyyes TMS

Study* findings show that energy metabolism is disturbed in individuals with MDD. The interplay of the gut microbiome and blood metabolome most likely plays a significant role in energy and lipid metabolism, as these changes in lipid metabolism are consistent with the gut dysbiosis and processes that are disrupted in and associated with individuals diagnosed with MDD.
* The cohort study used data from participants in the UK Biobank cohort (n = 500 000; aged 37 to 73 years whose blood was profiled for metabolomics and from the summary statistics from a 2019 genome-wide association study of depression were used for the mendelian randomization (individuals with MDD = 59 851; control individuals = 113 154).

Major depressive disorder linked to interplay of gut microbiome and blood metabolome An international team of medical researchers has found a link between major depressive disorder (MDD) and an interplay between the gut microbiome and the blood metabolome. For their study, reported in the journal JAMA Psychiatry, the group analyzed data in the UK Biobank.

A new sensitive and simple electrochemical sensor test for abnormal blood levels of dopamine detection in biological fluids could pave the way for the molecular diagnosis and earlier disorder/disease detection of neurological illnesses levels. The new procedure utilizes carbon quantum dots and an ionic liquid formulated with several mineral anions and organic cations for early detection of potential neurological disorders and diseases.

Could a new test that detects dopamine levels help diagnose neurological diseases? Altered levels of the neurotransmitter dopamine are apparent in various conditions, such as Parkinson's disease and depression.

Blood RNA transcripts reveal that multiple neurodegenerative diseases harbor similar (and differential) dysfunctional cellular alterations in their fundamental biological cell processes, including transcription regulation, degranulation, immune response, protein synthesis, apoptosis, cytoskeletal components, ubiquitylation/proteasome, and mitochondrial complexes that are also affected in the brain and reveal common themes across many neurodegenerative diseases. Identifying each regional vulnerability will reveal the unique disease mechanisms and ultimately lead to noninvasive treatments for neurological disorders and diseases.

Study Traces Shared and Unique Cellular Hallmarks Found in 6 Neurodegenerative Diseases - Neuroscience News Multiple neurodegenerative disorders harbor similar fundamental dysfunctional cellular processes.

Very well stated... "I think we need to spend more time talking about health and vitality and capabilities (instead of talking about disease and disability and death). And so we can change the tone of the conversation to prevention, instead of reaction." -- The University of Miami, Miller School of Medicine, Dr. James Galvin, director of the Comprehensive Center for Brain Health

Why do some people get Alzheimer's and others don't? How a new tool checks your risk Why do some people develop Alzheimer's disease and others don't? What makes one person's brain healthier than another's? And what can be done to improve, or at least slow, a brain's deterioration?