THE PIERCE GROUP

Congrats to Xiang on the total synthesis of bipolamine I, now online in JACS!

Total Synthesis of Bipolamine I Indolizidine alkaloids have been the target of chemical and biological studies for decades, most recently highlighted by the isolation of the curvulamine and bipolamine polypyrrole-containing subclass. Herein we report a stereoselective 15-step synthesis of bipolamine I, a distinct member of the bro...

Check out our Accounts article for the "Bacterial Multi-Drug Resistance" special issue. It provides an overview of our groups broader interests and some highlights of our recent work.

Leveraging Marine Natural Products as a Platform to Tackle Bacterial Resistance and Persistence ConspectusAntimicrobial resistance to existing antibiotics represents one of the greatest threats to human health and is growing at an alarming rate. To further complicate treatment of bacterial infections, many chronic infections are the result of bacterial biofilms that are tolerant to treatment w...