Herb-Science

About 1 in 3 people have the opposite problem. Their methylation isn’t slow — it’s already running at maximum. They have variants like COMT slow or MAOA slow, or they’re just generally what people call “highly sensitive.”

For someone in that group, a methylated B-vitamin doesn’t help. It floods an already-busy system with more methyl donors than it can handle. The result is what most people describe as feeling “wired” — anxiety, racing thoughts, jittery, can’t sit still, can’t sleep. Some people get heart palpitations. Some, like the woman who called me, feel angry instead of anxious.

These reactions usually show up within 30 minutes to a few hours of taking the supplement. They can last most of the day. And the kicker is, most people who experience them never connect the dots back to the B-complex. They blame stress, hormones, caffeine, whatever else is in their life. They might switch to a different B-complex brand and have the same problem, because the issue isn’t the brand — it’s the methylated forms.

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