Pediatric Infectious Disease Journal

Epidemiology of Invasive Group A Streptococcal Infections in Children in Los Angeles County, July 2023–June 2024

Alarming findings reported by this study:
Among 53 iGAS cases, 47% had potentially delayed diagnoses and 10% died.

Sherwood, Kyla; Dao, Bonnie; Gounder, Prabhu
https://journals.lww.com/pidj/fulltext/2026/06000/epidemiology_of_invasive_group_a_streptococcal.5.aspx?context=featuredarticles&collectionid=2


More info on Invasive Group A Strep:
📍Clinical manifestations include bacteremia, necrotizing soft tissue infections, osteoarticular infections, pleural empyema and toxic shock syndrome.
📍Risk factors include recent viral respiratory infection, immunosuppression (eg, HIV, corticosteroid use or diabetes mellitus) and disruptions to the skin barrier (eg, surgery).

Epidemiology of Invasive Group A Streptococcal Infections... : The Pediatric Infectious Disease Journal ion for iGAS in children with repeat clinical presentations or risk factors such as recent viral infections....

A new study highlights the association between early antibiotic exposure and risk of developing Celiac disease in children. The findings reinforce the need for cautious antibiotic prescribing practices in early childhood, to minimize unnecessary exposure.

Read full article here:
Early Antibiotics Usage During Infancy is Associated With High Risk of Celiac Disease Autoimmunity: A Population-based Study
Cozacov, Tal; Yackobovitch-Gavan, Michal; Guz-Mark, Anat; Shkalim-Zemer, Vered; Herman Cohen, Avner; Itzhaki Wygoda, Noam; Shouval, Dror S; Shamir, Raanan
https://journals.lww.com/pidj/fulltext/2026/06000/early_antibiotics_usage_during_infancy_is.1.aspx?context=featuredarticles&collectionid=2


More info on Celiac disease:
📍It is a common immune-mediated disorder, affecting approximately 1% of the general population.
📍While it classically presents with GI symptoms, it can also present through extraintestinal manifestations, including delayed growth, fatigue and iron deficiency anemia.
📍It primarily occurs in genetically predisposed individuals (HLA-DQ2 or HLA-DQ8 carriers) following dietary gluten exposure. However, genetic susceptibility alone cannot fully explain disease occurrence.
📍Increasing evidence suggests that environmental factors, gut microbiome alterations and GI infections play a pivotal role in disease development.
📍Relationship between early-life exposure to antibiotics and development of Celiac disease is an evolving topic in pediatric research.
📍Antibiotic-induced disruptions to the gut microbiota may play a key role in altering immune development and intestinal permeability, ultimately promoting autoimmune responses.

Burden of Hospitalized RSV in Children in Sweden: A Population-based Case-cohort Study (2006–2023)

Read this massive study from Sweden that analyzed national registry data from nearly 31,907 RSV cases, compared with 95,697 age-matched children.

During the study period, RSV accounted for 27% of all hospitalized acute respiratory infection cases.

Silfverdal Sven Arne, Holmgren Anton et al.

Burden of Hospitalized Respiratory Syncytial Virus in... : The Pediatric Infectious Disease Journal s critical to evaluate the potential impact of new prophylactic options. Methods: This case-cohort study used data from the Swedish national registers. However, 31,907 hospitalized RSV cases

Non-tuberculous meningitis (NTM) in children:

This study provides a comprehensive overview of clinical characteristics, management and treatment outcomes of children with infections in the Central Denmark Region between 2011 and 2023.

Cervical lymphadenitis has been reported to be the predominant clinical presentation, observed in over 90% of cases, supporting the existing literature.

Toustrup, Lise Bols; Holm, Emma; Lillebaek, Troels; Holm, Mette; Dahl, Victor N.
Read more

Diagnostics, Management and Outcomes of Pediatric... : The Pediatric Infectious Disease Journal cal characteristics, management and treatment outcomes of children diagnosed with NTM infections in the Central Denmark Region between 2011 and 2023. Children were identified using mycobacteriologic data and ICD-10 diagnostic codes. Detailed clinical information was extracted from hospital records,....