Intracellular Ion Channels Laboratory

Collaborated with Prof Rajaram on

Pseudomonas aeruginosa EVs Drive Cardiac Dysfunction During Infection. mBio.

This work demonstrates that extracellular vesicles (EVs) released by Pseudomonas aeruginosa are potent mediators of infection‑induced cardiac dysfunction.

Pseudomonas aeruginosa- mediated cardiac dysfunction is driven by extracellular vesicles released during infection - PubMed Pseudomonas aeruginosa (P.a.) is a gram-negative, opportunistic bacterium abundantly present in the environment. Often P.a. infections cause severe pneumonia, if left untreated. Surprisingly, up to 30% of patients admitted to the hospital for community- acquired pneumonia develop...

The first paper was

Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity. Nature Communications. This study uncovers a surprising and elegant layer of cellular regulation: extracellular vesicles (EVs) carry fully functional BK (large‑conductance Ca²⁺‑ and voltage‑activated K⁺) channels.

Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity - Nature Communications Extracellular vesicles secreted by cells play a crucial role in cellular communication. Here, the authors identify a functional BK channel in extracellular vesicle membranes and establish its role in preserving vesicle integrity, K+ homeostasis, and physiological function.

https://academic.oup.com/eurjpc/advance-article/doi/10.1093/eurjpc/zwaf137/8087961?login=true

Sodium or Potassium, and Chloride or Bicarbonate: Which Combination is Worth Its Salt? Ragavendra R Baliga, Harpreet Singh, Jagat Narula; Sodium or Potassium, and Chloride or Bicarbonate: Which Combination is Worth Its Salt?, European Journal