Nutritional Genomics Institute

You’ve tried everything.

Better sleep hygiene.
Less screen time.
Magnesium.
Melatonin.
The perfect nighttime routine.

And yet…

You still can’t fall asleep.
You wake up at 3 AM like clockwork.
Or you sleep 8–10 hours and still wake up exhausted.

Here’s what most people don’t realize:

Your circadian rhythm is heavily influenced by your genetics.

Variants in genes like **CLOCK, PER1, PER2, MTNR1A, MTNR1B, COMT, CRY1/2 and GAD1** can influence:
• when your body wants to sleep
• melatonin signaling
• cortisol rhythm
• sleep architecture
• stress resilience
• overnight recovery
• adaptation to shift work, time changes, and jet lag

This affects far more than sleep.

Poor circadian alignment can drive:
• weight gain
• weight loss resistance
• insulin resistance
• inflammation
• hormone disruption
• fatigue
• poor recovery

And yes—sometimes that stubborn weight gain isn’t just about calories.

Sometimes it’s circadian dysfunction, genetic predisposition, chronic artificial light exposure, and something as simple—but powerful—as inadequate morning sunlight.

At GenMedx, we use genomics and advanced testing to identify YOUR unique circadian and sleep patterns so we can build a strategy that works with your biology—not against it.

This isn’t generic sleep advice.

This is precision medicine.

Because better sleep—and better metabolism—starts with better data.