EndoCannabinoid System Education
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Today, Co-Founder of The AlcH**pist Austin Terry and ECS Scientist Chad Sallaberry will be discussing the importance of the Endocannabinoid System and a little bit about its impact on the immune system. We'll be covering a broad overview of the ECS as a whole, the interactions of h**p/cannabis with the ECS, and a brief dive into the immune system.
Recently, an incredibly interesting new article published in the peer-reviewed journal: The Journal of Natural Sciences, details how certain cannabinoids may hold therapeutic potential in treating COVID-19. The paper is called “Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768006/
Below, are a few key takeaways from the paper:
The scientists wanted to see if any cannabinoids could interact with a part of the COVID spike protein to prevent entry into cells
Of the three subunits that make up the spike protein (S1, S2, and S3) it appeared that certain cannabinoids did have an affinity for the S1 subunit of the spike protein
Specifically, CBDA, THCA-A CBGA, had what could we be deemed clinically relevant (low micromolar high nanomolar) affinities for the spike protein
After determining that they did indeed bind this protein, they wanted to see if the binding of the spike protein prevented cellular entry.
In cell work, they found that incubation of the COVID viruses with the cannabinoids did prevent viral entry into the cells, once again at clinically relevant levels.
This is a huge finding, and helps further emphasize the immense potential of cannabinoids therapeutic relevance.
While this study was a first step more than a means towards an end, it once again shows therapeutic potential of cannabinoids, making the FDA’s scheduling of cannabis as a schedule 1 drug (largely based on the claim of no currently accepted medical use) seem even more erroneous.
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