Lysosome Febs Advanced Course

We’re delighted to invite you to the FEBS Advanced Course, ”360-degree Lysosome; from structure to genomics, from function to disease-update”, which will be held in Kusadası between 4-9 October, 2022!

Dr. Andrea Ballabio is going to give an amazing lecture: “Lysosomes as dynamic regulators of cell and organismal homeostasis” in FEBS Advanced Lecture Course: 360° Lysosome on October 7, 2021 at 9.30 am!
Dr. Andrea Ballabio obtained his M.D. degree at the University of Naples, Italy, where he completed his residency in Pediatrics. After working as post-doctoral fellow at the Institute of Genetics and Biophysics in Naples and at Guy’s hospital in London UK, in 1989 he moved to the Department of Molecular and Human Genetics of Baylor College of Medicine in Houston TX USA, where he became Associate Professor and Co-director of the Human Genome Center. At the end of 1994 he moved back to Italy to become the founder and director of the Telethon Institute of Genetics and Medicine (TIGEM). He is Professor of Medical Genetics at the Faculty of Medicine of the University of Naples “Federico II” and Visiting Professor at both Baylor College of Medicine in Houston, Texas. He was two-time winner of the Advanced European Research Council (ERC) 5 year-grant, in 2010 and in 2016. He was the winner of the 2106 Louis-Jeantet prize for Medicine. He is a Co-Founder of CASMA Therapeutics, a company focused on autophagy and based in Boston, MA. He has authored over 350 publications in international peer-reviewed journals.
The focus of Andrea Ballabio's research career has been on the elucidation of the mechanisms underlying genetic diseases. The contributions of his laboratory have spanned a wide range of biological processes and human diseases, from X chromosome-inactivation (the discovery of Xist), axonal targeting (Kallmann syndrome), melanosome biogenesis (Ocular albinism), mitochondrial biogenesis (Hereditary spastic paraplegia), embryonic development (Chondroplasia punctata and Opitz GBBB syndrome) and post-translational protein modification (Multiple sulfatase deficiency) to name a few. In the past few years he has focused his research on the lysosome and on the role of lysosomal dysfunction in lysosomal storage diseases (L*D) and common neurodegenerative diseases. His group discovered that in L*Ds lysosomal dysfunction leads to a block of the autophagic pathway with consequent accumulation of autophagy substrates, which contributes to the development of neurodegeneration in these diseases. More recently, his group discovered that lysosomal function and autophagy are subject to a global transcriptional regulation, which is mediated by the master gene TFEB.

*Ds