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OSTEOSARCOMA arising in a 17 year old male patient!

THE RADIOGRAPHIC SIGNS:
1- Widening of the PDL membrane space (Garrington sign)
2- Sun ray appearance
MICROSCOPICALLY:
The lesion shows malignant undifferentiated spindle cells with evidence of cartilage differentiation and MOST IMPORTANTLY OSTEID DEPOSITION . Perivascular arrangment was also evident ( high risk factor for metastasis)
Immunophenotyping :
The lesion was negative for cytokeratn, desmin, myogenin, S100 and LCA
Positive for Vimentin and Osteopontin

OSTEOSARCOMA OF THE GNATHIC BONES DO NOT REQUIRE INDUCTION CHEMOTHERAPY ( as opposed to other osteosarcomas)

Kindly check the description on the pictures
Courtesy of Dr. Youssef el Mansy

Periodontolgy Paper 2021 Supplementry