Helminth Therapy

"Treatment of moderate to severe IBD involves the use of immune modulators and/or biologics, which have several toxicities and side effects, such as predisposition to infections, cancer, and demyelinating diseases in addition to others. Helminths or helminth products are attractive therapeutic avenues given their safety profile... Further research on helminths is expected to be rewarding in physiological and biochemical characterization of not only helminthic immune modulation to identify novel, potent, and safe approaches to treat IBD but also to result in discovery of novel and common immune regulatory pathways useful in the management of other immune pathologies."

Abstract:
(https://pubmed.ncbi.nlm.nih.gov/37189818/)

Full Text:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135676/

Helminth Lessons in Inflammatory Bowel Diseases (IBD) - PubMed Helminths are multicellular invertebrates that colonize the gut of many vertebrate animals including humans. This colonization can result in pathology, which requires treatment. It can also lead to a commensal and possibly even a symbiotic relationship where the helminth and the host benefit from ea...