Computational and Structural Biotechnology Journal

Special Issues This issue aims to bring together cutting-edge research and integrative reviews at the intersection of metabolomics, microbiome science, and computational biology to advance the One Health agenda.

🔬 A breakthrough for spatial biology? This ultrafast 3D imaging method enables deep whole-organ visualization faster than ever before.

This study introduces an ultrafast 3D immunolabeling and tissue-clearing workflow that enables whole-organ imaging in just 2 to 2.5 days, representing a major advancement in high-resolution biological imaging and quantitative tissue analysis. The method combines rapid immunostaining, optimized tissue clearing, and light sheet microscopy to visualize intact murine and human tissues with remarkable speed and precision.

📝 Junyu Chen, Zhangfan Ding, Lincoln Biswas, Jessica De Angelis, Alexandros Chatzis, Anjali P. Kusumbe

🔗 Rapid 3D Immunolabeling and Light Sheet Microscopy for Quantitative Analysis of Intact Tissues. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0121

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science, Sichuan University, MIA Portugal, Nanyang Technological University, Singapore

⚛️ What if randomness inside cells isn’t noise — but biology’s hidden operating system?

This study introduces a hybrid Physics-Informed Neural Network (PINN) and Bayesian modeling framework to analyze how single nanoparticles adhere to living cells under different cytoskeletal perturbations — offering a major advancement for nanomedicine, drug delivery, and mechanobiology. The framework combines classical viscoelastic physics with AI-driven learning to accurately model complex and noisy biological interactions.

📝 Houari Bettahar, Hélder A. Santos, Quan Zhou

🔗 Hybrid Physics-Informed and Bayesian Modeling of Single-Nanoparticle–Cell Adhesion Kinetics under Cytoskeletal Perturbation. Computational and Structural Biotechnology Journal (CSBJ). DOI: https://doi.org/10.34133/csbj.0077

📚 CSBJ - A Science Partner Journal: https://spj.science.org/journal/csbj

Aalto University, University of Helsinki, UMCG - Universitair Medisch Centrum Groningen, University of Groningen, Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science

CSBJ Smart Hospital (https://spj.science.org/journal/csbj/smarthospital), is inviting submissions for its upcoming special issue:

“Data Orchestration in Smart Health: From Raw Biomedical Data to AI-Ready Frameworks”

📌 Topics include (but are not limited to):
• Wearable physiological signal preprocessing (EEG, ECG, PPG, EMG, EDA, accelerometry)
• Medical imaging pipelines for AI (MRI, CT, ultrasound, histopathology)
• Multi-omics integration and AI-readiness
• EHR extraction, normalization, and clinical NLP
• FAIR data principles and benchmark dataset construction
• Annotation frameworks and weak supervision
• Federated learning, privacy-preserving AI, GDPR/HIPAA compliance
• Bias mitigation and reproducibility in biomedical AI
• Cloud-native biomedical AI workflows and clinical deployment pipelines

⏳ Submission Deadline: 30 December 2026

🔗 For more info about the Call for Papers, please visit: https://spj.science.org/journal/csbj/si/data-orchestration

🧠 Guest Editors:
• Eleni Kaldoudi, Δημοκρίτειο Πανεπιστήμιο Θράκης/Democritus University of Thrace, Greece
• Vaidotas Marozas, KTU Kauno technologijos universitetas/Kaunas University of Technology, Lithuania
• Antti Vehkaoja, Tampere University, Finland

Computational and Structural Biotechnology Journal, Science Partner Journals, AAAS - The American Association for the Advancement of Science