UIRRG

Our latest paper on Kir2.1 ion channel trafficking, and its dependence on the cytoskeleton, has just been published in Frontiers in Physiology.

Quantitative Analysis of the Cytoskeleton’s Role in Inward Rectifier KIR2.1 Forward and Backward Trafficking Alteration of the inward rectifier current IK1, carried by KIR2.1 channels, affects action potential duration, impacts resting membrane stability and associates with cardiac arrhythmias. Congenital and acquired KIR2.1 malfunction frequently associates with aberrant ion channel trafficking. Cellular....

We just published our latest work on the development of IKATP inhibitors. A good collaboration with our friends in Vienna.

Development of IKATP Ion Channel Blockers Targeting Sulfonylurea Resistant Mutant KIR6.2 Based Channels for Treating DEND Syndrome Introduction: DEND syndrome is a rare channelopathy characterized by a combination of developmental delay, epilepsy and severe neonatal diabetes. Gain of function mutations in the KCNJ11 gene, encoding the KIR6.2 subunit of the IKATP potassium channel, stand at the basis of most forms of DEND syndro...

Our latest review on the CAVB dog and its place in pharmacological research for over the last 100 years is now published open access.

BPS Publications Ventricular cardiac arrhythmia is a life threating condition arising from abnormal functioning of many factors in concert. Animal models mirroring human electrophysiology are essential to predict and...

We just published our work on the development of new Kir2 channel agonists, that we call AgoKirs.

https://www.mdpi.com/1422-0067/21/16/5746/htm