Advanced Medical Biotechnology

Title: Nanoindentation and nano scratch investigations on graphene-based nanocomposites (Shokrieh et al., 2012)

Summary: The effect of graphene nano-platelets (GNPs) on the mechanical properties of polymer nanocomposites was investigated using nanoindentation and nano scratch methods. Using a typical Berkovich indenter at three different normal loads of 400, 600, and 800 mN with the addition of 0.05 wt% GNP, both elastic modulus and hardness increased by 83%. A nano scratch test combined with atomic force microscopy (AFM) was used to evaluate the tribological behavior of nanocomposites showed reduced pile-up and high wear resistance.

Source: http://dx.doi.org/10.1016/j.polymertesting.2012.09.001
SHARED BY: Alif Haikal Elias

Title: Proteomics of Streptococcus mutans to Reveal the Antibiofilm Formation Mechanism of Ag/ZnO Nanocomposites with Light-Emitting Diode Radiation (Jiang et al., 2021)

Summary: Synergistic therapy happens when the combined effect of two or more treatments is better than the total of the effects seen when each agent is given alone. This therapy able to destroyed the majority of bacteria such as Streptococcus mutans and prevented the remaining bacteria from developing biofilms. Proteomics investigation of S. mutans after synergistic therapy and subsequent metabolic studies revealed the mechanism of antibiofilm development on sucrose metabolism and D-alanine metabolism.

Source: https://doi.org/10.2147/IJN.S333432
SHARED BY: Alif Haikal Elias

Title: Enhanced Bone Remodelling Effects of Low-Modulus Ti−5Zr−3Sn−5Mo−25Nb Alloy Implanted in the Mandible of Beagle Dogs under Delayed Loading (Hu et al., 2019).

Summary: The Ti−5Zr−3Sn−5Mo−25Nb (TLM) alloy group showed a considerable increase in the proportion of bone-implant interface contact, the bone inside the thread, mineralization, crystallinity, modulus of elasticity, and hardness of the integrated bone after delayed loading. The outcome is desirable for biomechanical compatibility especially in stress conditions resulted in desirable biomechanical compatibility, particularly when subjected to applied stress.

Source: 10.1021/acsomega.9b02580
SHARED BY: Alif Haikal Elias

TITLE: cumin-loaded electrospun PHBV nanofibers as potential wound dressing material (Mutlu et al., 2018)

Curcumin-loaded PHBV nanofibers with high curcumin concentration, 25 µmol/L, increased the cell attachment and proliferation thus being suitable for a wound-dressing material. Moreover, PHBV/Cur nanofibers were not toxic to L929 mouse fibroblasts in the MTT assay test and were biodegradable under enzymatic conditions.

Source: https://doi.org/10.1016/j.jddst.2017.09.017
Shared by: Khairun Nabihah

TITLE: Cordycepin Nano-encapsulated in Poly (Lactic-Co-Glycolic Acid) Exhibits Better Cytotoxicity and Lower Hemotoxicity Than Free Drug (Marslin et al., 2020)

Cordycepin-loaded PLGA nanoparticles (CPNPs) are an encapsulated drug for cancer treatment. CPNPs exhibited a high level of cellular uptake and cytotoxicity 3 times lower than the free drug in MCF-7 cells. This CPNP was also able to release the encapsulated cordycepin sustainably over 10 days for great effect.

Source: https://doi.org/10.2147/NSA.S254770
Shared by: Khairun Nabihah