Fucoidan Japan

ANTICANCER PROPERTIES

A diet high in fucoidan may also help prevent and treat cancer. Memorial Sloan-Kettering Cancer Center says several laboratory studies have shown that fucoidan has medicinal properties that could be helpful in combating some forms of cancer but cautions that human data thus far are lacking. The center cites one study that showed fucoidan appears to inhibit the spread of cancerous cells by preventing the adhesion of tumor cells to the extracellular matrix. In another study, fucoidan induced apoptosis, or programmed cell death, in human T-cell leukemia virus type I, or HTLV-1, that causes adult T-cell leukemia. The polysaccharide paves the way for apoptosis by inactivating NF-kB, a naturally occurring substance that regulates antiapoptotic proteins.

Cholangiocarcinoma

Male in the 80s
Chief Complaint: Jaundice
Past Medical history: No significant diseases

Current medical history:
He visited a nearby hospital complaining of, primarily, jaundice in July 2013. In a bile duct cancer examination, tumors were found in the hepatic portal section and the bile duct, and obstructive jaundice was developed. A PTCD-tube was inserted on July 16, 2013 and followed by a stent on August 23 in an attempt to reduce pressure in the bile duct and mitigate jaundice. He visited our hospital seeking for palliative care in September 9, 2013. He began fucoidan therapy, without any aggressive treatments including chemotherapy (his family members also declined such treatments), taking his age into consideration.

Treatment Outcomes:
His tumor shrank with only fucoidan therapy. CA-19-9 levels were improved to 434.4 from 1170, and the levels of ALP were improved to 509 from 1179, and the levels of γ-GTP also were improved to 13 from 230. The jaundice disappeared and he had no further pain.

※Data taken over the period of treatment

《CT images of the abdomen》

Fucoidan mix intake per day: Approximately 4.0g

September 2013

June 2014



【Tumor markers】

September 2013June 2014CA19-9(≦ 37.0)1170.0434.4(U/ml)



【Biochemistry tests】

September 2013June 2014ALP(115 ~ 359)1179509(U/l)γ-GTP (< 70)23013(U/l)

Bile duct cancer, liver metastasis and bone metastasis

Male in his 40s
Chief Complaint: No significant symptoms
Past Medical History: Not significant

Current Medical History:
In March 2011, he was diagnosed with stage Ⅳ bile duct cancer, and the tumor had spread to the liver and bones. In April the same year, he began fucoidan therapy in combination with chemotherapy.

Treatment Outcomes:
He began fucoidan therapy in April 2011. By July the same year, the size of tumor was reduced to 2.0cm × 2.0cm from 2.9cm × 2.3cm. There were no side effects from chemotherapy, and the QOL was also improved.

※Data taken over the period of treatment

《CT images of abdomen》

Fucoidan mix intake per day: Approximately 5.0ｇ

Tumor size：2.9cm×2.3cm
March 2011

Tumor size：2.0cm×2.0cm
July 2011

Fucoidan mix・・・It is composed of mozuku extracted fucoidan, mekabu extracted fucoidan and agaricus mycelium.

Today, active research is conducted on fucoidan and various bioactive functions of fucoidan, such as “anti-cancer action,” “cholesterol-lowering action,” “blood-pressure lowering action” and “anti-virus action,” have been revealed.

Left o***y cancer, Cancerous peritonitis, Cancerous ascites

Female in the 30s
Chief Complaint: Abdominal fullness
Past Medical History: Not significant

Current Medical History:
She visited a university hospital due to abdominal fullness in October 2003, and was diagnosed with left ovarian cancer, carcinomatous peritonitis and carcinomatous ascites. She was advised to have a surgery, chemotherapy and radiation therapy, but she refused any of them. She visited our clinic in November to seek a second opinion as well as information on fucoidan. Similarly, we advised her to have a surgery, chemotherapy and radiation therapy, but she refused. After she was provided with sufficient information on fucoidan mix, she began fucoidan mix only therapy.

Treatment Outcome:
Her tumor markers were lowered, and CT images showed that her tumor had reduced from 11cm to 6cm.

※Data taken over the period of treatment

《CT images of the pelvis》

Fucoidan mix intake per day: Approximately 8.0g
※ At the time of data

November 2003

January 2004

August 2005



【Tumor markers】

November 2003November 2004August 2005CA19-9 (< 37.0)10762.457002573(U/ml)CA125 (< 35.0)1076.2820220.4(U/ml)

Data provided by Matsuzaki Memorial Hospital

Fucoidan mix・・・It is composed of mozuku extracted fucoidan, mekabu extracted fucoidan and agaricus mycelium.

Today, active research is conducted on fucoidan and various bioactive functions of fucoidan, such as “anti-cancer action,” “cholesterol-lowering action,” “blood-pressure lowering action” and “anti-virus action,” have been revealed.