The Le Grand Lab

We publish our latest pre-print today on BioRxiv. Have a look and let us know what you think!

High-dimensional single-cell cartography reveals novel skeletal muscle resident cell populations Adult tissue repair and regeneration require the activation of resident stem/progenitor cells that can self-renew and generate differentiated progeny. The regenerative capacity of skeletal muscle relies on muscle satellite cells (MuSCs) and their interplay with different cell types within the niche....

Our latest paper is published today in the new journal Cell Discovery. Check out our work, it is the first ever demonstration of the control of a histone methyltransferase sub-cellular localization by an extracellular signaling pathway.

Canonical Wnt signalling regulates nuclear export of Setdb1 during skeletal muscle terminal differentiation Cell Discovery, Published online: 18 October 2016; | doi:10.1038/celldisc.2016.37

Latest team picture, taken by our friend Bruno Cadot.

media.giphy.com https://media.giphy.com/media/JIX9t2j0ZTN9S/giphy.gif

Visiting Hong Kong University of Science & Technology to work with my colleague Tom Cheung.
http://cheunglab.ust.hk