PREP lab

One more paper out for this year from PREP lab, this time to Biochemical Pharmacology! In this study by Hengjing Cui et al., we showed that PREP regulates not only macroautophagy but also chaperone-mediated autophagy and acts a link between these cellular recycling mechanisms.

This is also important for alpha-synuclein degradation as it can be cleaved via both autophagy mechanisms.

Prolyl oligopeptidase acts as a link between chaperone-mediated autophagy and macroautophagy The accumulation of aggregated α-synuclein (α-syn) has been identified as the primary component of Lewy bodies that are the pathological hallmarks of …