Immuno ICS

Aire-expressing ILC3-like cells in the lymph node display potent APC features The autoimmune regulator (Aire) serves an essential function for T cell tolerance by promoting the “promiscuous” expression of tissue antigens in thymic epithelial cells. Aire is also detected in rare cells in peripheral lymphoid organs, but the identity of these cells is poorly understood. Here...

Something really great is happening in gene therapy, already correcting the germinal line,
When could be applied to somatic cells?

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23305.html
A dream coming true?

http://www.nature.com/nature/journal/vaop/ncurrent/full/nature23305.html

Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research Nature | Article Print Share/bookmark Cite U Like Facebook Twitter Delicious Digg Google+ LinkedIn Reddit StumbleUpon Previous article Nature | News and Views Biotechnology: At the heart of gene edits in human embryos Next article Nature | Article Integrative clinical genomics of metastatic cancer C...

Fantastic advices!!! not always easy to follow
http://dx.plos.org/10.1371/journal.pcbi.0030213

Ten Simple Rules for Doing Your Best Research, According to Hamming Erren TC, Cullen P, Erren M, Bourne PE (2007) Ten Simple Rules for Doing Your Best Research, According to Hamming. PLoS Comput Biol 3(10): e213. https://doi.org/10.1371/journal.pcbi.0030213

A new neurological autoimmune disease

Autoimmunity in nodding syndrome

Nature 542, 395 (23 February 2017) doi:10.1038/542395d

In Tanzania, Uganda and South Sudan, nodding syndrome causes children's heads to drop and results in epileptic seizures, cognitive impairment and sometimes death. Although people with the syndrome are often infected with the parasitic worm Onchocerca volvulus (pictured), researchers have not found a causal link between the two.

Now, a team led by Avindra Nath at the National Institute of Neurological Disorders and Stroke in Bethesda, Maryland, has discovered that people with nodding syndrome have higher levels of antibodies against a protein called leiomodin-1 than do healthy people from the same village. The researchers show that leiomodin-1 is made by human neurons and by key parts of the mouse brain. This protein is structurally similar to those made by O. volvulus, and antibodies that react against O. volvulus do the same against leiomodin-1, suggesting an autoimmune response.

People with the syndrome currently receive anti-epilepsy drugs, but the findings suggest that they might also benefit from therapies that modulate the immune system, the authors say.

Sci. Transl. Med. 9, eaaf6953 (2017)