Pharmaforfun

As a junior clinical pharmacist, I
believe in self learning. To me, every drug holds a mystery waiting to be discovered, and every clinical case offers a new piece of information to add to my growing experience. I've decided to share my self learning journey, my quest to uncover every detail, no matter how simple or well known it might be to others. For me, each one is a discovery, and it's the first time I've ever heard of it! 😉"

"Today, we're going to talk about Nimodipine, a unique calcium channel blocker. (I only recently learned about it.)

Unlike its counterparts, Nimodipine is a highly cerebroselective, oral calcium-channel blocker. Due to its targeted action on cerebral arterioles, it is used to treat subarachnoid hemorrhage (SAH) rather than hypertension, which is the common indication for other dihydropyridines.

This preferential effect on the central nervous system's vasculature with minimal impact on peripheral arteries is attributed to Nimodipine's high lipophilicity. This unique property is the basis for its use in preventing neurologic deficits following SAH, which are often caused by cerebral vasospasm. It also explains its role in managing migraines."

دايمًا في الصيدلية بشوف روشتات كتيرة من دكاترة النسا مكتوب فيها المنيوريل أكياس اللى مادته الفعالة مضاد حيوي وهو الفوسفومايسن و استغربت كمان أنه بيتعطي دايما كجرعة واحدة بس وكمان مفيش أقراص خالص عندنا في الصيدلية فيها الفوسفومايسن ك مادة فعالة والطريقة الوحيدة اللى بيتاخد بيها أورال بتكون عن طريق الأكياس ف عشان كده قولت لازم نتكلم عليه النهاردة. 😉
As a new community pharmacist I always see doctors prescribing Monoril sachets to their female patients, and the dosage is always one sachet as a single dose, so i woundred why doctors may write monuril as a single dose and i noticed that i have never seen any tablets or capsules containing fosfomycin which is the active constituent of monuril so i decided to google it to find answers to all my questions about monuril and i I will share it with you in this post

first of all Monuril sachets contain the active ingredient "fosfomycin trometamol" which is an antibiotic used to treat bladder infections (such as acute cystitis or lower urinary tract infections) in women.

the commercially available formulations for oral fosfomycin treatment are fosfomycin trometamol and fosfomycin calcium.

Fosfomycin trometamol, which is a phosphonic acid derivative of fosfomycin, Its commercially available oral formulation consists of a single-dose sachet that contains white granules.

Fosfomycin calcium salt is the second commercially available formulation for oral fosfomycin treatment. It consists of a white tablet of 500 mg of fosfomycin

fosfomycin trometamol is now the preferred oral formulation due to its improved properties compared to fosfomycin calcium, including higher bioavailability (F) which ranges from 33% to 44% (compared to 12–37% for the calcium salt.

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