Inheritome

🍽️Is Mediterranean diet a "magic potion" for lipid traits? Perhaps. But not for all🤔

Recent study shows that this popular nutrition plan really does improve weight, waist circumference and glucose, but total cholesterol improvement on the Mediterranean diet depends on the person's genetic risk score (GRS).

Genetic risk score is the sum of person's risk alleles for markers from the selected genetic panel. In this study the GRS was calculated for high BMI predisposition panel. It was shown that low GRS (which means lower predisposition to high BMI) is associated with cholesterol improvement on the Mediterranean diet, whereas high GRS - is not.

Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study. - PubMed - NCBI Nutrients. 2017 Oct 11;9(10). pii: E1107. doi: 10.3390/nu9101107.

👨‍⚕️Deep vein thrombosis (DVT) is a serious condition caused by a clot formation in veins, leading to the redness, swelling and possible detachment of the clot. Detached clot goes through the vascular system and may cause arteries embolisation - a life-threatening event.

🕵️‍♂️DVT may have a genetic background and be linked to some mutations in the coagulation proteins genes. One of the frequent causes of DVT is Factor V mutation (or Leiden mutation). People with rs6025 A variant have 3.5-4x higher risk of thrombosis, which is even higher, up to 6x, in women taking oral contraceptives. Homozygous variant (AA) means 11x higher risk.

💊Anticoagulation therapy is often used for people with Leiden mutation to prevent dangerous coagulation events, but because of the side effects this therapy is possible only under a strict doctor's control.

🔬People with DVT should check their rs6025 genotype to learn about their F5 and possible cause of thrombosis.
https://www.inheritome.com/blog.html

Inheritome Genetic Blog

Saliva sampling: simple and painless👨‍🔬
Modern lab genotyping analysis uses a saliva sample to get a person's DNA. Why is it possible?

Our saliva has buccal cells, and DNA is extracted from them. All our cells has same genetic information, so buccal epithelium is OK to get all necessary for genotyping. This means you don't need to pass blood collecting for modern DNA testing, you just need to spit into a collecting kit, following simple collecting rules📝

Recent study shows, that up to 90% of Canadians with gluten intolerance don't know they have this condition (BMJ Open, October,2017). 🚫🍞🍺
Gluten intolerance is genetically linked disease, so DNA testing may help to reveal unfavorable markers. Read more in our genetic blog: https://www.inheritome.com/blog/gluten-free-or-not.html

Gluten-free or not?