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Volatile PFAS and the Role of TD-GC-MS/MS 12/05/2026

Volatile PFAS demand a new playbook 🔬⚙️. Daniela Cavagnino, M.S. (Thermo Fisher Scientific) shows why TD‑GC‑MS/MS underpins two complementary methods:

• ASTM D8591‑24 🧪: Targets FTOHs and neutral PFAS in chamber/ambient air. Enables product stewardship and indoor air assessments with ng/m³ sensitivity (~780 pg/m³ in 20 L). µ‑CTE studies found 8:2 FOET dominant, emission rate 0.131 ng/g/min.

• EPA OTM‑50 🏭: Verifies PFAS destruction at stationary sources, tracking VFCs like CF₄. Addresses ultra‑volatiles, high CO₂ (±30% bias check), humidity, and ppt‑level detection.

Thermo Scientific workflows:

• D8591‑24: TD100‑xr + TRACE 1610 GC + TSQ 9610, with automated IS addition, dry purge, cryogen‑free focusing, and Chromeleon CDS 📈.

• OTM‑50: Markes UNITY‑xr preconcentration, dedicated traps, ISQ 7610 or TSQ 9610 for added selectivity ✅.

One platform, distinct strategies: What do products emit? What remains after destruction? ♻️

Volatile PFAS and the Role of TD-GC-MS/MS ASTM D8591-24 and EPA OTM-50 highlight differences between volatile PFAS emissions testing and PFAS destruction verification using TD-GC-MS/MS.

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