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🧬 mAb manufacturing, made simple. Maria Gruebner (Thermo Fisher Scientific) reveals how switchable 2D‑LC‑UV‑MS puts CQAs under near real‑time control.

• 🧪 1D ProA cleanup, then toggle: SCX for charge or SEC for size—no replumbing.
• 📈 UVD for rapid trendlines; 🧠 HRAM‑MS for intact‑level insights into glycoforms, modifications, and aggregates.
• ⏱️ At‑line in ~1 h from bioreactor to insight; catch glycation, deamidation, drift, and aggregation early.
• 💸 Cut scrap, protect yield, avoid restarts; standardized AQbD workflow eases transfer and scale‑up.

Outcome: fewer surprises, faster course corrections, and steadier biotherapeutics. ✅

Monitoring mAb Manufacturing the Easy Way with Switchable 2D‑LC-UV-MS Switchable 2D-LC-UV-MS workflows enable rapid monitoring of mAb quality attributes and support timely process interventions.