Supervised Injectable Opioid Agonist Treatment

Oral and injectable opioid agonist treatments for people who use street opioids: a systematic literature review and network meta-analysis
Nick Bansback et al. BMC Public Health. 2025.

« Diacetylmorphine plus oral methadone was associated with a smaller proportion of participation in criminalized activities relative to methadone alone.

Conclusion: Both diacetylmorphine and injectable hydromorphone supplemented with methadone showed favourable retention compared to methadone and buprenorphine, depending on the strength of the OAT being co-prescribed or being compared to. These results provide further support for alternatives to conventional OATs such as diacetylmorphine or injectable hydromorphone for treatment retention. »

Oral and injectable opioid agonist treatments for people who use street opioids: a systematic literature review and network meta-analysis - PubMed Both diacetylmorphine and injectable hydromorphone supplemented with methadone showed favourable retention compared to methadone and buprenorphine, depending on the strength of the OAT being co-prescribed or being compared to. These results provide further support for alternatives to conventional OA...