Indicar - Interdisciplinary Cancer Research

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Our fellow Nicola Silva has published as co-author in PLOS Genetics: “C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata”. Congratulations Nicola!

C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata Author summary The creation of a viable individual from the fusion of egg and s***m requires that they each contain the correct number of chromosomes. This is ensured through the meiotic divisions, which initially fasten identical chromosomes together through DNA linkages that hold them together unt...

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The INDICAR-Fellow Nicola Silva has published as corresponding author in PLOS Genetics: “BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis”. Congratulations Nicola!!

BRCA1-BARD1 associate with the synaptonemal complex and pro-crossover factors and influence RAD-51 dynamics during Caenorhabditis elegans meiosis Author summary Sexually reproducing species rely on meiosis to transmit their genetic information across generations. Parental chromosomes (homologues) undergo many distinctive processes in their complex journey from attachment to segregation. The physiological induction of DNA double strand breaks....

The INDICAR-Workshop 2018 took place in Bratislava (Slovakia), from 13th to 14th Sep. The INDICAR Workshop is the opportunity for post-doctoral researchers enrolled in the INDICAR Program to discuss common themes and exchange cross-disciplinary results with a particular focus on the techniques used to reach their goals. As the INDICAR Programme ends November 2018, the fellows presented and discussed their work with a particular focus on how to wrap up outcomes and what the results may mean for future research.

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Our fellow Luca Tubiana just published as corresponding author in the European Physical Journal E Soft Matter: “Implementing efficient concerted rotations using Mathematica and C code⋆”. Congratulations, Luca! 👍👏👏

https://link.springer.com/article/10.1140/epje/i2018-11694-7

Implementing efficient concerted rotations using Mathematica and C code⋆

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The INDICAR-Fellow Luca Tubiana has published as corresponding author in the European Physical Journal E Soft Matter: “KymoKnot: A web server and software package to identify and locate knots in trajectories of linear or circular polymers”, and his research article has been featured on the cover! Congratulations Luca!!🎉👏👏

KymoKnot: A web server and software package to identify and locate knots in trajectories of linear or circular polymers Abstract. The KymoKnot software package and web server identifies and locates physical knots or proper knots in a series of polymer conformations. It is mainly intended as an analysis tool for...

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Our fellow Alessio Terenzi has published as co-author in the European Journal of Medicinal Chemistry: “Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction”. Congratulations!!👍👏
https://www.sciencedirect.com/science/article/pii/S0223523418305476

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The INDICAR-Fellow Nicola Silva co-authored a PLoS Genetics publication: “The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans”. Congratulations Nicola!
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007453