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Scientists have long known that the brain’s visual system isn’t fully hardwired from the start — it becomes refined by what babies see — but the authors of an MIT study still weren’t prepared for the degree of rewiring they observed when they took a first-ever look at the process in mice as it happened in real-time.

As the researchers in The Picower Institute for Learning and Memory tracked hundreds of “spine” structures housing individual network connections, or “synapses,” on the dendrite branches of neurons in the visual cortex over 10 days, they saw that only 40 percent of the ones that started the process survived. Refining binocular vision (integrating input from both eyes) required numerous additions and removals of spines along the dendrites to establish an eventual set of connections.

Former graduate student Katya Tsimring led the study, published this month in Nature Communications, which the team says is the first in which scientists tracked the same connections all the way through the “critical period,” when binocular vision becomes refined.

“What Katya was able to do is to image the same dendrites on the same neurons repeatedly over 10 days in the same live mouse through a critical period of development, to ask, what happens to the synapses or spines on them?,” says senior author Mriganka Sur, the Paul and Lilah Newton Professor in the Picower Institute and MIT’s Department of Brain and Cognitive Sciences. “We were surprised by how much change there is.”

More: https://bcs.mit.edu/news/connect-or-reject-extensive-rewiring-builds-binocular-vision-brain

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