Project ALS
The future of ALS research is being shaped by bold ideas and collaborative science.
In partnership with Charles River Labs, Project ALS co-founder, Valerie Estess, joins a woman living with ALS for a conversation about the science driving today's ALS research. Together, they explore promising areas of investigation, including gene therapy and other approaches that are helping researchers better understand how we can move toward effective treatments.
07/04/2026
Wishing our entire Project ALS community a happy and safe Fourth of July!
We are grateful to have each and every one of you as part of this community. Every step we take together helps move ALS research forward and brings us closer to better treatments and a cure.
Happy Fourth!✨
The ALS Hater tee is now available in brand-new colors! Show your support for ALS research in a way that fits your style. Every purchase helps fuel ALS research and bring us closer to a future without this horrible disease.
Which color are you grabbing first? https://www.bonfire.com/als-hater-zip-up-1/ 👀
06/25/2026
Would you like to get down in the mud, test your strength, and also raise funds for ALS research? 💪🏼
If you answered yes to all three of those questions, we have great news! You can now fundraise for Project ALS when you compete in a Tough Mudder course.
Explore available Tough Mudder courses: https://toughmudder.com/events/
06/24/2026
My aunt was diagnosed with ALS in 2017. That diagnosis is devastating under any circumstance, but it felt especially terrifying because a close family friend had died from ALS just a few years earlier. After watching what he endured, it was unimaginable to think that she might face the same thing.
The hardest part for me was watching her lose the ability to speak. She had the best laugh and such a beautiful voice. I remember sitting with her that Christmas after we learned of her diagnosis. By then, it had become so difficult to understand what she was trying to say.
It broke my heart to watch her try so hard to communicate, and for us not to be able to understand her. With our family friend, we watched the disease progress to the point that he communicated by using his toe to point to letters. Watching that was heartbreaking, and I was not prepared to see my aunt begin to go through the same thing.
When she passed away just a few months later, in June 2018, it was unbearable. At the same time, there was also a sense of relief that she never had to experience the very final stages of the disease.
ALS is one of the most heartbreaking diseases because the person is still fully there mentally. They can still think, feel, understand, and know exactly what is happening. Losing someone to ALS is incredibly painful, but watching someone live with it can be just as painful.
06/23/2026
Today is Together Tuesday! 🫂
This week, we're inviting you to leave a Note of Hope for someone affected by ALS.
A few kind words can brighten a day, offer encouragement, or remind someone they're not facing this journey alone.
💌 Choose who you would like to write your note to
💌 Leave your note in the comments or send it to us in a DM
💌 Use
We'll be sharing your notes on our Notes of Hope page so that these messages can continue reaching people who need them.
Read some Notes of Hope here: https://projectals.org/notes-of-hope/. ♥️
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