Healthwise

This is why imipenem is usually given with the dhp-1 inhibitor, cilastin👇

Dihydropetidase-1 (DHP1) is an enzyme found mainly in the kidneys, especially in the cells lining the renal tubules.

What does it do?
It helps break down dipeptides (small protein fragments), particularly:
-Glutathione-related compounds
-Certain drug metabolites

So basically, it plays a role in:
Protein metabolism
Detoxification processes in the kidney

Why is it clinically important?

1. Drug metabolism (very important 💊)
DHP1 is involved in breaking down some antibiotics, especially:
Imipenem

Without control, DHP1 rapidly destroys imipenem in the kidney, making it ineffective and potentially harmful to the kidneys.

That’s why imipenem is always given with:
Cilastatin
Cilastatin blocks DHP1, allowing imipenem to:

-Last longer in the body
-Work effectively
-Reduce kidney toxicity

2. Kidney function
Since DHP1 is abundant in the kidney:
It contributes to renal handling of peptides and drugs.

It plays a role in protecting the body from toxic metabolites.

see the biochemistry behind point no. 1👇👇

Happy world immunization week

Let's have it✍️✍️

"Contrary to the narratives, Minister Mercy did not initiate any court action against Eezeetee regarding her music catalog. At no point did she claim that a 50/50 revenue split from her DSP earnings is unfair. Commencing the third year of working with Eezeetee, things began to change gradually. He expressed his intentions for her to extend her five-year contract to twelve years; however, she declined.

After she noticed at any given opportunity to discuss the issue, Eezeetee would be hostile and refer to the contract, which was not the norm. Shockingly, it turned out that the contract that was signed in 2017 had been replaced by another made in 2019.

Eezeetee was the one who filed a curt case against Mercy Chinwo and Judikay. The same person pushed the false report of Minister Mercy taking him to court to mislead the public to pity him." - Mercy Chinwo shares a legal statement concerning the court case against her former manager Eezeetee.

Photo credit: mercychinwo eezeetee1/Instagram