Al Barka Health Care

LASSA FEVER

Key facts

Lassa fever is an acute viral haemorrhagic illness of 2-21 days duration that occurs in West Africa.
The Lassa virus is transmitted to humans via contact with food or household items contaminated with rodent urine or faeces.
Person-to-person infections and laboratory transmission can also occur, particularly in hospitals lacking adequate infection prevention and control measures.
Lassa fever is known to be endemic in Benin, Ghana, Guinea, Liberia, Mali, Sierra Leone, and Nigeria, but probably exists in other West African countries as well.
The overall case-fatality rate is 1%. Observed case-fatality rate among patients hospitalized with severe cases of Lassa fever is 15%.
Early supportive care with rehydration and symptomatic treatment improves survival.
Background

Though first described in the 1950s, the virus causing Lassa disease was not identified until 1969. The virus is a single-stranded RNA virus belonging to the virus family Arenaviridae.

About 80% of people who become infected with Lassa virus have no symptoms. 1 in 5 infections result in severe disease, where the virus affects several organs such as the liver, spleen and kidneys.

Lassa fever is a zoonotic disease, meaning that humans become infected from contact with infected animals. The animal reservoir, or host, of Lassa virus is a rodent of the genus Mastomys, commonly known as the “multimammate rat.” Mastomys rats infected with Lassa virus do not become ill, but they can shed the virus in their urine and faeces.

Because the clinical course of the disease is so variable, detection of the disease in affected patients has been difficult. When presence of the disease is confirmed in a community, however, prompt isolation of affected patients, good infection prevention and control practices, and rigorous contact tracing can stop outbreaks.

Lassa fever is known to be endemic in Benin (where it was diagnosed for the first time in November 2014), Ghana (diagnosed for the first time in October 2011), Guinea, Liberia, Mali (diagnosed for the first time in February 2009), Sierra Leone, and Nigeria, but probably exists in other West African countries as well.

Symptoms of Lassa fever

The incubation period of Lassa fever ranges from 6–21 days. The onset of the disease, when it is symptomatic, is usually gradual, starting with fever, general weakness, and malaise. After a few days, headache, sore throat, muscle pain, chest pain, nausea, vomiting, diarrhoea, cough, and abdominal pain may follow. In severe cases facial swelling, fluid in the lung cavity, bleeding from the mouth, nose, va**na or gastrointestinal tract and low blood pressure may develop.

Protein may be noted in the urine. Shock, seizures, tremor, disorientation, and coma may be seen in the later stages. Deafness occurs in 25% of patients who survive the disease. In half of these cases, hearing returns partially after 1–3 months. Transient hair loss and gait disturbance may occur during recovery.

Death usually occurs within 14 days of onset in fatal cases. The disease is especially severe late in pregnancy, with maternal death and/or fetal loss occurring in more than 80% of cases during the third trimester.

Transmission

Humans usually become infected with Lassa virus from exposure to urine or faeces of infected Mastomys rats. Lassa virus may also be spread between humans through direct contact with the blood, urine, faeces, or other bodily secretions of a person infected with Lassa fever. There is no epidemiological evidence supporting airborne spread between humans. Person-to-person transmission occurs in both community and health-care settings, where the virus may be spread by contaminated medical equipment, such as re-used needles. Sexual transmission of Lassa virus has been reported.

Lassa fever occurs in all age groups and both sexes. Persons at greatest risk are those living in rural areas where Mastomys are usually found, especially in communities with poor sanitation or crowded living conditions. Health workers are at risk if caring for Lassa fever patients in the absence of proper barrier nursing and infection prevention and control practices.

Diagnosis

Because the symptoms of Lassa fever are so varied and non-specific, clinical diagnosis is often difficult, especially early in the course of the disease. Lassa fever is difficult to distinguish from other viral haemorrhagic fevers such as Ebola virus disease as well as other diseases that cause fever, including malaria, shigellosis, typhoid fever and yellow fever.

Definitive diagnosis requires testing that is available only in reference laboratories. Laboratory specimens may be hazardous and must be handled with extreme care. Lassa virus infections can only be diagnosed definitively in the laboratory using the following tests:

reverse transcriptase polymerase chain reaction (RT-PCR) assay
antibody enzyme-linked immunosorbent assay (ELISA)
antigen detection tests
virus isolation by cell culture.
Treatment and prophylaxis

The antiviral drug ribavirin seems to be an effective treatment for Lassa fever if given early on in the course of clinical illness. There is no evidence to support the role of ribavirin as post-exposure prophylactic treatment for Lassa fever.

There is currently no vaccine that protects against Lassa fever.

Prevention and control

Prevention of Lassa fever relies on promoting good “community hygiene” to discourage rodents from entering homes. Effective measures include storing grain and other foodstuffs in rodent-proof containers, disposing of garbage far from the home, maintaining clean households and keeping cats. Because Mastomys are so abundant in endemic areas, it is not possible to completely eliminate them from the environment. Family members should always be careful to avoid contact with blood and body fluids while caring for sick persons.

In health-care settings, staff should always apply standard infection prevention and control precautions when caring for patients, regardless of their presumed diagnosis. These include basic hand hygiene, respiratory hygiene, use of personal protective equipment (to block splashes or other contact with infected materials), safe injection practices and safe burial practices.

Health-care workers caring for patients with suspected or confirmed Lassa fever should apply extra infection control measures to prevent contact with the patient’s blood and body fluids and contaminated surfaces or materials such as clothing and bedding. When in close contact (within 1 metre) of patients with Lassa fever, health-care workers should wear face protection (a face shield or a medical mask and goggles), a clean, non-sterile long-sleeved gown, and gloves (sterile gloves for some procedures).

Laboratory workers are also at risk. Samples taken from humans and animals for investigation of Lassa virus infection should be handled by trained staff and processed in suitably equipped laboratories under maximum biological containment conditions.

On rare occasions, travellers from areas where Lassa fever is endemic export the disease to other countries. Although malaria, typhoid fever, and many other tropical infections are much more common, the diagnosis of Lassa fever should be considered in febrile patients returning from West Africa, especially if they have had exposures in rural areas or hospitals in countries where Lassa fever is known to be endemic. Health-care workers seeing a patient suspected to have Lassa fever should immediately contact local and national experts for advice and to arrange for laboratory testing.

SUDDEN CARDIAC ARREST

Sudden cardiac arrest is the abrupt loss of heart function, breathing and consciousness. The condition usually results from an electrical disturbance in your heart that disrupts its pumping action, stopping blood flow to your body.
Sudden cardiac arrest differs from a heart attack, when blood flow to a part of the heart is blocked. However, a heart attack can sometimes trigger an electrical disturbance that leads to sudden cardiac arrest.

If not treated immediately, sudden cardiac arrest can lead to death. With fast, appropriate medical care, survival is possible. Giving cardiopulmonary resuscitation (CPR), using a defibrillator — or even just giving compressions to the chest — can improve the chances of survival until emergency workers arrives.

Symptoms
Sudden cardiac arrest signs and symptoms are immediate and drastic and include:
Sudden collapse
No pulse
No breathing
Loss of consciousness
Sometimes other signs and symptoms occur before sudden cardiac arrest. These might include:
Chest discomfort
Shortness of breath
Weakness
Palpitations
But sudden cardiac arrest often occurs with no warning.
When to see a doctor
See your doctor promptly if you have episodes of:
Chest pain or discomfort
Heart palpitations
Rapid or irregular heartbeats
Unexplained wheezing
Shortness of breath
Fainting or near fainting
Lightheadedness or dizziness

When the heart stops, the lack of oxygenated blood can cause death or permanent brain damage in minutes. Time is critical when you're helping an unconscious person who isn't breathing.
If you see someone who's unconscious and not breathing normally, do the following:

Perform CPR. Quickly check the breathing. If the person isn't breathing normally, begin CPR. Push hard and fast on the person's chest — at the rate of 100 to 120 compressions a minute. If you've been trained in CPR, check the person's airway and deliver rescue breaths after every 30 compressions.
If you haven't been trained, just continue chest compressions. Allow the chest to rise completely between compressions. Keep doing this until a portable defibrillator is available or emergency workers arrive.
Use a portable defibrillator, if one is available. It will give you step-by-step voice instructions. Continue chest compressions while the defibrillator is charging. Deliver one shock if advised by the device and then immediately resume CPR, starting with chest compressions, or give chest compressions only, for about two minutes.
Using the defibrillator, check the person's heart rhythm. If necessary, the defibrillator will give another shock. Repeat this cycle until the person recovers consciousness or emergency workers take over.
Portable automated external defibrillators (AEDs) are available in many places, including airports, casinos and shopping malls. You can also purchase one for your home. AEDs come with built-in instructions for their use. They're programmed to allow a shock only when appropriate.

Causes
A problem in your heart rhythm (arrhythmia) — the result of a problem with your heart's electrical system — is the usual cause of sudden cardiac arrest.

The heart's electrical system controls the rate and rhythm of your heartbeat. If something goes wrong, your heart can beat too fast, too slowly or irregularly (arrhythmia). Often these arrhythmias are brief and harmless, but some types can lead to sudden cardiac arrest.

The most common heart rhythm at the time of cardiac arrest is an arrhythmia in a lower chamber of your heart (ventricle). Rapid, erratic electrical impulses cause your ventricles to quiver uselessly instead of pumping blood (ventricle fibrillation).

Heart conditions that can lead to sudden cardiac arrest
Sudden cardiac arrest can happen in people who have no known heart diease. However, a life-threatening arrhythmia usually develops in a person with a pre-existing, possibly undiagnosed heart condition. Conditions include:

Coronary artery disease. Most cases of sudden cardiac arrest occur in people who have coronary artery disease, in which your arteries become clogged with cholesterol and other deposits, reducing blood flow to your heart.

Heart attack. If a heart attack occurs, often as a result of severe coronary artery disease, it can trigger ventricular fibrillation and sudden cardiac arrest. Also, a heart attack can leave scar tissue in your heart. Electrical short circuits around the scar tissue can lead to abnormalities in your heart rhythm.

Enlarged heart (cardiomyopathy). This occurs primarily when your heart's muscular walls stretch and enlarge or thicken. Then your heart's muscle is abnormal, a condition that often leads to arrhythmias.

Valvular heart disease. Leaking or narrowing of your heart valves can lead to stretching or thickening of your heart muscle. When the chambers become enlarged or weakened because of stress caused by a tight or leaking valve, there's an increased risk of developing arrhythmia.

Congenital heart disease. When sudden cardiac arrest occurs in children or adolescents, it can be due to a heart defect that was present at birth (congenital heart disease). Adults who've had corrective surgery for a congenital heart defect still have a higher risk of sudden cardiac arrest.
Electrical problems in the heart. In some people, the problem is in the heart's electrical system itself instead of a problem with the heart muscle or valves. These are called primary heart rhythm abnormalities and include conditions such as Brugada's syndrome and long QT syndrome.

Risk factors
Because sudden cardiac arrest is so often linked with coronary artery disease, the same factors that put you at risk of coronary artery disease can also put you at risk of sudden cardiac arrest. These include:
A family history of coronary artery disease
Smoking
High blood pressure
High blood cholesterol
Obesity
Diabetes
A sedentary lifestyle
Other factors that might increase your risk of sudden cardiac arrest include:
A previous episode of cardiac arrest or a family history of cardiac arrest
A previous heart attack
A personal or family history of other forms of heart disease, such as heart rhythm disorders, congenital heart defects, heart failure and cardiomyopathy
Age — the incidence of sudden cardiac arrest increases with age
Being male
Using illegal drugs, such as co***ne or amphetamines
Nutritional imbalance, such as low potassium or magnesium levels
Obstructive sleep apnea
Chronic kidney disease
Complications
When sudden cardiac arrest occurs, reduced blood flow to your brain causes unconsciousness. If your heart rhythm doesn't rapidly return to normal, brain damage occurs and death results. Survivors of cardiac arrest might show signs of brain damage.

Prevention
Reduce your risk of sudden cardiac arrest by getting regular checkups, being screened for heart disease and living a heart-healthy lifestyle.

Its Monday💃💃!

✔️A big welcome to new members.
✔️Set urself 3 goals dis week. ✔️Prioritise 3 tasks everyday & watch ur productivity grow -

Here is another 5 days to achieve great things.

Do have a productive Monday💕

https://chat.whatsapp.com/DSytDJHrjc3JODnLlULwtc

WhatsApp Group Invite WhatsApp Messenger: More than 1 billion people in over 180 countries use WhatsApp to stay in touch with friends and family, anytime and anywhere. WhatsApp is free and offers simple, secure, reliable messaging and calling, available on phones all over the world.