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Anastrozole Impurities

Anastrozole was first approved for use in the United States in 1995. Anastrozole is a non-steroidal aromatase inhibitor (AI), similar to letrozole, used to decrease circulating estrogen levels in the treatment of postmenopausal women with estrogen-responsive breast cancer. Anastrozole is also related to exemestane, a steroidal AI, but its non-steroidal nature provides stark advantages including a lack of steroid-associated adverse effects such as weight gain and acne. Aromatase inhibitors, including anastrozole, have become endocrine drugs of choice in the treatment of postmenopausal breast cancer due to a more favorable efficacy and adverse effect profile as compared to earlier estrogen receptor modulators such as tamoxifen. Anastrozole Impurities are primarily used as a reference standard in the pharmaceutical industry for analytical method development and validation to detect and quantify trace levels of this potential contaminant during the manufacturing process of the Anastrozole. It can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Anastrozole.

Anastrozole Impurity A Anastrozole Impurity B
Anastrozole Impurity D Anastrozole Impurity I

All impurities will be shared with all characterization data such as 1H NMR, 13C NMR, HPLC, MS, IR, TGA.

All Impurities are in stock with us.

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Tacrolimus Impurities

Tacrolimus (also FK-506 or Fujimycin) is an drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo. It was discovered in 1984 from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis. Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription. Tacrolimus Impurities are primarily used as a reference standard in the pharmaceutical industry for analytical method development and validation to detect and quantify trace levels of this potential contaminant (a nitrosamine impurity) during the manufacturing process of the Tacrolimus. It can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tacrolimus.

All impurities will be shared with all characterization data such as 1H , 13C NMR, HPLC, MS , IR, TGA

All are in stock with us.

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Abhay Gandhi Pritam Gandhi Cro Splen Cro Splendid Lab Pvt. Ltd.

Molecule of the week by Splendid lab - N-Nitroso N-Desmethyl Edoxaban Impurity 1

is a medication used to prevent blood clots and reduce the risk of stroke in atrial fibrillation as well as treat and prevent deep vein thrombosis (DVT) and pulmonary embolism (PE). -Nitroso -Desmethyl Edoxaban 1 is primarily used as a in the pharmaceutical industry for method development and validation to detect and quantify trace levels of this potential contaminant (a nitrosamine impurity) during the manufacturing process of the drug Edoxaban. It can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Edoxaban.

CAS No: NA
Molecular Formula: C23H27ClN8O5S
Molecular Weight: 563.03

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