Ivffreelancing

Ivffreelancing

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Photos 04/07/2013
Photos 07/03/2013

Aspirin and heparin as adjuvants during IVF do not improve live birth rates in unexplained implantation failure:

A significant proportion of fertility units worldwide advise women to take low-dose aspirin and/or heparin following embryo transfer to improve the chance of embryo implantation, particularly in cases of repeated IVF failure. However, a recent published study from the Nottingham group failed to show any benefit of using low-dose aspirin and/or heparin as adjuvant therapies during IVF in an unselected group of subfertile women who have previously had one or more unexplained implantation failure following IVF. On the contrary, there was a non-significant trend of reducing the chance of live birth in the aspirin and/or heparin group. This cohort–control study recruited 234 consecutive subjects aged 44 years who had previously had one or more unsuccessful IVF cycle. All underwent IVF using conventional long agonist or short antagonist protocols. The study group received aspirin and/or heparin post embryo transfer until the day of pregnancy test or until 12 weeks of pregnancy. The control group did not receive any adjuvant treatment. There was no statistically significant difference in the live birth rate (35.0% versus 47.6%) clinical pregnancy rate (40.8% versus 53.4%) and miscarriage rate (14.3% versus 10.9%) between the study group and the control group. The article can be retrieved through the link
http://www.rbmojournal.com/article/S1472-6483(13)00071-0/abstract

http://www.lifeinvitro.com/NEWs/fullnews.php?fn_id=10

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