Dityatev Lab

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Supply chain logistics?

This new review out of the University of Manchester () discusses the role of the Golgi complex in production and maintenance.

Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance | Journal of Cell Science | The Company of Biologists John Hellicar, Nicola L. Stevenson, David J. Stephens, Martin Lowe; Supply chain logistics – the role of the Golgi complex in extracellular matrix production and maintenance. J Cell Sci 1 January 2022; 135 (1): jcs258879. doi: https://doi.org/10.1242/jcs.258879

A study on the mechanisms of synaptic insulin resistance is online - thanks to the ENERGI consortium and our collaboration with the Michael Kreutz group:

Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease - Translational Neurodegeneration Background The metabolic syndrome is a consequence of modern lifestyle that causes synaptic insulin resistance and cognitive deficits and that in interaction with a high amyloid load is an important risk factor for Alzheimer's disease. It has been proposed that neuroinflammation might be an interven...

Copy number variants in neurexin genes: phenotypes and mechanisms

Copy number variants in neurexin genes: phenotypes and mechanisms - PubMed Neurexins are central to trans-synaptic cell adhesion and signaling during synapse specification and maintenance. The past two decades of human genetics research have identified structural variations in the neurexin gene family, in particular NRXN1 copy number variants (CNVs), implicated in multiple...