DIAL

Can you detect multiple fluorophores with a limited number of light sources? Yes you can! In this exciting work by Dr. Niesner's group, in which we were happy to participate, we used triple two-photon excitation with spatiotemporal synchronization of two femtosecond lasers to achieve just this.

Synergistic Strategy for Multicolor Two-photon Microscopy: Application to the Analysis of Germinal Center Reactions In Vivo Simultaneous detection of multiple cellular and molecular players in their native environment, one of the keys to a full understanding of immune processes, remains challenging for in vivo microscopy. Here, we present a synergistic strategy for spectrally multiplexed in vivo imaging composed of (i) t...

In this work from our lab, Sebastian Papazoglou et al. have developed a normalization method for routine MRI, which greatly decreases COV between subjects. Using this approach we were able to detect white matter gender difference using only a very small sample size, which have been previously shown with DTI in a much larger cohort. We are now looking into how this method can be applied to detect tissue changes in neuroinflammatory diseases.

Single‐subject independent component analysis‐based intensity normalization in non‐quantitative multi‐modal structural MRI Non‐quantitative MRI is prone to intersubject intensity variation rendering signal intensity level based analyses limited. Here, we propose a method that fuses non‐quantitative routine T1‐weighted (T1w),...

Have I really not updated this page since January? There goes my New Year's resolution to post more regularly.